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HLA-B27 Uveitis in Chinese – An Analysis of 510 patients |
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| HLA-B27 Uveitis in Chinese – An Analysis of 510 patients |
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作者：Yu-Mei C… 文章来源：Uveitis Service, Department of Ophthalmology, National Yang-Ming University School of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan.201, Sec.2 Shihpai Rd., Taipei 112-17, Taiwan 点击数：4066 更新时间：2006/7/11 18:06:19 
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| Purpose: HLA-B27 uveitis is the most common type of endogenous uveitis in Taiwan. The clinical features consist of a unilateral nongranulomatous anterior uveitis of sudden onset and limited duration. It appear to be both genetic and environmental contributions to the development of the episode. One of the environmental factors is a seasonal variation. On the other hand, HLA-B27 antigen is also highly linked to the spondyloarthropathies, a group disorders including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, enteropathic arthritis, and undifferentiated spondyloarthropathies. The main objectives in this study were to assess the clinical features of HLA-B27 uveitis in Chinese patients.
Methods: A retrospective study of 510 consecutive patients seen at the uveitis clinic in Taipei Veterans General Hospital during a period of 18 years between 1987 and 2004. All patients manifested a typical acute anterior uveitis and with positive HLA-B27 antigen. Rheumatologist was consulted simultaneously if spondyloarthropathy was highly suspected.
Results: Three hundred fourty patients (67%) were male and 170 patients (33%) were female, with male to female ratio of 2 to1. The median age at the time of the first attack of uveitis was 36 years, with 37 in male and 34 in female. (P>0.05) The mean age at the time of the first attack of uveitis was 36±13.2 years, with 39±14.3 in the male and 35±10 in the female. (P>0.05) Of the 510 patients, 1020 uveitis attacks were recorded. The monthly distribution of 1020 attacks showed a significant monthy variation with the high incidence falling from December to February. (P<0.01) Ankylosing spondylitis was diagnosed in 213 patients(41.8%) at the first visit and increased to 45.9% at the last visit.
Conclusions: A male predominance, a relative young age, a prominent seasonal variation and high association of spondyloarthropathy were found in Chinese patients with HLA-B27 uveitis.
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